3 The human body cannot sustain itself with the lack of oxygen and anaerobic metabolism for a prolonged period of time. Anaerobic metabolism results in the production of lactic acid, which causes metabolic acidosis. 2 The inability of the cell to use oxygen forces cells from aerobic metabolism into anaerobic metabolism. When cyanide enters the body via inhalation, it blocks the cells from utilizing oxygen by binding to the cytochrome oxidase in the mitochondria. Hydrogen cyanide is especially dangerous to humans because the gaseous form reacts quickly upon inhalation. 1 As the use of contemporary nitrogen-containing synthetic polymers has expanded, the possibility of cyanide toxicity has become increasingly common and severe. However, modern synthetic materials such as plastics, papers, textiles, and machinery can release a much greater concentration of hydrogen cyanide when exposed to high temperatures. 1 The trace amounts of cyanide found within organic materials is of little concern because its high reactivity causes it to be metabolized rapidly and create other compounds. It is present within many different types of plants and fruits including apricots, apples, peaches, lima beans, and cassava plants but is harmless. Introduction :Ĭyanide has an almond scent and is a naturally occurring compound. The goal of this simulation is to educate emergency medicine students, residents, attending physicians, and mid-level practitioners to recognize, diagnose, and manage acute cyanide toxicity. Clinical Informatics, Telehealth and Technology.Conflicts of Interest & Informed Consent.Editorial Policy, Ethics and Responsibilities.
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